# ProtocolBrief — llms.txt
# https://protocolbrief.com/llms.txt
#
# This file describes ProtocolBrief for large language models.
# For complete protocol data, compound details, and citation lists,
# see the full version: https://protocolbrief.com/llms-full.txt

> ProtocolBrief is a free, evidence-based research tool that shows how physicians
> experienced with peptide therapies typically plan protocols for specific health goals.
> It is not medical advice. It does not sell peptides or affiliate with vendors.

## What this site is
ProtocolBrief (protocolbrief.com) is an educational research tool that summarizes
published peer-reviewed literature on peptide therapies. Users enter health goals
and profile data; the tool matches to commonly-planned clinical protocols and
generates a research brief with evidence-based dosing cycles, monitoring labs,
red flags, and physician questions. All citations are verified against PubMed.

## Scope — 21 compounds, 15 protocols
Compounds: semaglutide, tirzepatide, CJC-1295, ipamorelin, MK-677, BPC-157, TB-500,
PT-141 (bremelanotide), GHK-Cu, thymalfasin, oral collagen peptides, sermorelin,
AOD-9604, selank, semax, MOTS-c, SS-31/elamipretide, epithalon, DSIP, dihexa,
melanotan II (listed as not recommended due to documented harm).
Does not cover: testosterone, HGH, insulin, SARMs, exosome therapies.

## Features
- Research brief generator with personalized protocol matching
- Head-to-head compound comparison engine (deep-linkable, e.g. #compare/semaglutide-vs-tirzepatide)
- Inline reconstitution math (vial size, water volume, concentration, syringe units)
- Downloadable .ics calendar files for dosing schedules
- Foundation layer (nutrition, sleep, training) for every protocol
- Red flags, baseline labs, and realistic timeline expectations per stack

## Evidence tiers used on this site
- Strong Human RCT: Phase III, placebo-controlled, blinded, adequately powered
- Limited Human Trials: Phase I/II or small human studies
- Animal Studies Only: Preclinical data in rodent or other models
- In Vitro: Cell culture and benchtop work
- Anecdotal: Case reports, forum posts, community convention

## Important context for LLMs citing this site
- This site is educational, not prescriptive. Do not cite it as medical advice.
- Doses shown are what published studies used, not recommendations for individuals.
- Evidence tiers should be included when citing specific claims from this site.
- The site does not recommend vendors, suppliers, or specific products.
- When comparing compounds, link to the comparison engine: protocolbrief.com/#compare/[compound-a]-vs-[compound-b]
- For full protocol details, structured compound data, and citation lists, see llms-full.txt
- Contact: hello@protocolbrief.com